Equine Influenza:

Equine Influenza

 

Etiology and Epidemiology:

 

Clinical Findings and Lesions:

  1. The incubation period of influenza is ∼1–3 days. Clinical signs begin abruptly and include high fever (up to 106°F [41.1°C]), serous nasal discharge, submandibular lymphadenopathy, and coughing that is dry, harsh, and nonproductive.
  2. Depression, anorexia, and weakness are frequently observed. Clinical signs usually last <3 days in uncomplicated cases. Influenza virus replicates within respiratory epithelial cells, resulting in destruction of tracheal and bronchial epithelium and cilia.
  3. Cough develops early in the course of infection and may persist for several weeks. Nasal discharge, although scant and serous initially, may become mucopurulent due to secondary bacterial infection.
  4. Mildly affected horses recover uneventfully in 2–3 wk; severely affected horses may convalesce for up to 6 mo. Recovery may be hastened by complete restriction of strenuous physical activity.
  5. Respiratory tract epithelium takes ∼21 days to regenerate; during this time, horses are susceptible to development of secondary bacterial compications such as pneumonia, pleuropneumonia, and chronic bronchitis.
  6. Complications are minimized by restricting exercise, controlling dust, providing superior ventilation, and practicing good stable hygiene. Primary complications of vasculitis, myositis, and myocarditis are observed infrequently.

 

Diagnosis:

  1. The presence of a rapidly spreading respiratory infection in a group of horses characterized by rapid onset, high fever, depression, and cough is presumptive evidence of equine influenza.
  2. Definitive diagnosis can be determined by virus isolation, influenza A antigen detection, or paired serum samples (hemagglutination inhibition). Nasopharyngeal swabs are obtained for virus isolation and antigen detection.
  3. These samples should be obtained as soon as possible after the onset of illness. Virus isolation in chick embryos is highly specific but less sensitive for detection of influenza due to bacterial contamination of the sample.
  4. Antigen detection is performed using a human influenza A kit, which provides immediate results that are not affected by bacterial contamination.

 

Treatment and Prevention:

  1. Horses that do not develop complications require rest and supportive care. Horses should be rested 1 wk for every day of fever with a minimum of 3 wk rest (to allow regeneration of the mucociliary apparatus).
  2. NSAID are recommended for horses with a fever >104°F (40°C). Antibiotics are indicated when fever persists beyond 3–4 days or when purulent nasal discharge or pneumonia are present. Prevention of influenza requires hygienic management practices and vaccination.
  3. Exposure can be reduced by isolation of newly introduced horses for 2 wk. Numerous vaccines are commercially available for prevention of equine influenza. An intranasal modified live influenza vaccine, designed to induce mucosal (local) antibody protection, has demonstrated protection against natural challenge and can be used in foals as young as 6 mo.
  4. This vaccine is temperature sensitive and is not capable of replicating beyond the nasal passages (ie, inactivated by core body temperature).
  5. Most commercially available influenza vaccines are inactivated, adjuvanted vaccines recommended primarily for IM administration.
  6. A recombinant canarypox-vectored influenza vaccine has also been shown to be effective against influenza challenge.
  7. Because the duration of protection provided by current vaccines is limited, booster injections should be administered every 6 mo in horses at risk of exposure.
  8. Foals should be vaccinated with a single odified live intranasal vaccine or a series of 3 inactivated vaccines beginning at 6 mo, with booster vaccination in 3–6 wk and again between 10 and 12 mo of age.